CimplSoft is a privately held software company providing information and knowledge management solutions. The insight and experience gained by a researcher is often lost because the current productive and analytics software can only deal with a specific task at hand. The connected nature of insight and experience can only be captured if the applications themselves are connected. We created COnstruct cheMical and BIological NEtwork (COMBINE) to solve this problem by creating “smart” nodes and connecting them interactively to build a knowledge network. COMBINE is designed to handle all aspects of drug discovery and can be used to perform data organization, data sharing, data visualization, and data analysis.